Claudio Guillén (September 2, 1924, Paris – January 27, 2007, Madrid), was a Spanish writer.
He was a son of the poet Jorge Guillén, with whom he left his country in 1939 to live in exile in the United States. He specialized in comparative literature, and, between 1965 and 1985, he was a professor of this subject at the University of California, San Diego, Princeton University and Harvard University. In 1982, he returned to Spain, and he taught comparative literature at the University of Barcelona. In 1999, he was rewarded with the National Prize of Essay, for his essay "Múltiples moradas". Since March 2002, he was a member of the Spanish Royal Academy.